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In poorly managed T2DM treated with basal insulin, tirzepatide can improve glucose control without hypoglycemia risk, alone or in combination with other oral hypoglycemic medications [79]

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This early evaluation provided the framework for the dose-escalation algorithms used in later phase 3 trials [3]

Its structure is significantly more complex than simpler peptides, involving a precise sequence of amino acids modified to enhance its stability and half-life in a biological system

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