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eLife 12 , e82938 (2023)

Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

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It repairs and maintains the gut lining, which is the critical physical barrier that prevents toxins from entering the bloodstream a condition commonly called leaky gut. When this barrier is compromised, bacterial toxins (endotoxins) pass directly into circulation and reach the liver, dramatically increasing its workload