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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

The main factors that are generally associated with elevations of homocysteine are nutritional deficiency, particularly related to folate metabolism, mutations of the enzymes MTHFR and CBS (Aguilar)

It is important to distinguish between theoretical concerns based on mechanism of action and actual clinical evidence of harm

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Results: Based on the small intestinal transcriptome of geniposide, a recognized small-molecule GLP-1R agonist, we identified that cinchonine exerted GLP-1R agonist-like effects