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Increasing NAD+ via NR supplementation reduced type-I interferon (IFN) signaling, which plays an important role in immune response. Twelfth Human Niagen Study That Demonstrates Effectiveness: Another 2022 study assessed the tolerability, safety, and cerebral penetration of NR therapy (1,000mg per day for 30 days) in humans

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Going one step further, researchers showed that tryptase and the number of mast cells are both elevated in the joints of people with osteoarthritis