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In January 2025 , a narrative review in Cureus evaluated the efficacy and safety of oral, topical, and intravenous glutathione for skin lightening

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This research showed that GSH supplementation of amino acids (including L-glycine) and micronutrients (including vitamin C, vitamin E, and magnesium), as well as specific dietary patterns (vegetarian, the Mediterranean diet, and the DASH diet) had the potential to raise glutathione concentrations, which in turn slowed the rate of tissue deterioration