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Under steady-state conditions, this GSSG is rapidly exported to extracellular fluid, potentially contributing to the higher levels of GSSG measured in asthmatic BAL fluid, while also contributing to an altered intracellular redox balance

Moffitt et al., 2018

16 However, the burden of gastrointestinal side effects and challenges with long-term adherence limited its broader applicability and underscored the need for more effective and better-tolerated therapeutic alternatives

All experiments were performed in accordance with relevant guidelines and regulations

For pipeline context and head-to-head insights, see Orforglipron vs Rybelsus for how next-generation oral options may compare in practice, and follow Orforglipron Clinical Trials for updated results and milestones