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369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

Patients undergoing bariatric or hernia procedures were excluded to better isolate the effects of GLP-1 therapy

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males +7.5 points) but lowered body weight to a greater extent in females (average difference in females 9.6%

Each of these agents also influences markers of inflammation, endothelial function, and even brain metabolismkey pathways in aging