The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)
In SH-SY5Y cell cultures, semaglutide was shown to protect against A 25-35, through enhancement of autophagy and inhibition of apoptosis [55]
For some individuals, this can cause undernutrition, and for others, it may contribute to rebound preferences for sugars and refined carbohydrates if they delay eating until they are overly hungry
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3)
Since then, shes cycled through all sorts of eating and exercise plans