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Future investigations should delve deeper into the immune regulatory mechanisms of PSA and PAGln in specific infection models (e.g., pneumonia) and their functional interplay in the context of host-microbiota interactions

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Notably, the age-related increases in nitration of ECM-bound HGF were predominant on fast IIa and IIx myofibers 32 , corresponding with the fast fiber-preference observed in age-related muscle atrophy and impaired regeneration in humans in which fast IIb fibers are scarce 33,34,35, 39