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In clinical studies, liraglutide and semaglutide both led to an average 0.3-point drop in A1c in prediabetic participants (after 56 weeks for liraglutide 5 and 68 weeks for semaglutide 6 )a small but meaningful shift for people whose blood sugar is creeping upward toward the diabetes threshold

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This further supports oral semaglutide as effective despite long-standing T2D and comorbidities

Unrecognized hypo- and hyperglycemia in well-controlled patients with type 2 diabetes mellitus: the results of continuous glucose monitoring

The risk is severe caloric restriction that drops below 800 to 1,000 calories per day, which triggers metabolic adaptation, muscle loss, nutrient deficiencies, and hormonal disruption