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Two extracellular loops of occludin, rich in glycine and tyrosine residues, interact with neighbouring occludins on adjacent cells, contributing to the paracellular barrier by restricting macromolecule flux while allowing small ion passage (Furuse et al., 1994)

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doi: 10.1016/j.apsb.2022.06.003 56 ChiouHYCLinMWHsiaoPJChenCLChiaoSLinTYet al

These data support an inter-organ crosstalk driven by WAT lipolysis, likely through cooperative GCGR and FGF21-mediated lipolysis, adiponectin secretion and liver-derived FGF21, in favoring EE and body weight loss

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