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4 Skin estrogen biosynthesis Despite the gonads being the primary source of androgens and estrogens, active sex steroids are also synthesized locally in peripheral tissues from circulating precursors (Pomari et al., 2015)
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Similar content being viewed by others Main Cells that undergo senescence stably exit the cell cycle and display distinct phenotypic changes, which include the production of a bioactive secretome (the senescence-associated secretory phenotype (SASP)), reprogramming their metabolism and becoming more resistant to cell death 1
