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A similar mechanism has been described for the prion protein PrP, wherein its mislocalization to the cytosol enables aberrant binding to cytosolic ubiquitin ligase, sequestering the enzyme and reducing its functional availabilitythereby contributing to neurodegeneration 82

Biomarker selection is another methodological challenge

However, since these compounded versions are not regulated to the same standards as FDA-approved medications, their safety, efficacy, and consistency may vary, raising important concerns for consumers

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