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the first step is conjugation of glutamic acid and cysteine, which is catalyzed by glutamate-cysteine ligase and generates -glutamyl-cysteine (-Glu-Cys) and the second step is catalyzed by glutathione synthase, which adds glycine to -Glu-Cys, forming glutathione

Magnetic resonance imaging (MRI) and computed tomography (CT) are alternative options, though they do not reliably capture the full histopathologic spectrum of NAFLD

Singh S, Bodas M, Bhatraju NK, et al

The more accessible targets may already have been over-exploited

The change affects so-called GLP-1 medications FDA-approved for weight loss, including brand names such as Wegovy and Zepbound