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Evidence from in vitro and in vivo studies demonstrates that melatonin downregulates steroidogenic acute regulatory (StAR) protein and 3-hydroxysteroid dehydrogenase expression under OS conditions, thus restraining excessive androgen synthesis (196), an effect particularly relevant in PCOS, where HA disrupts follicular development

They scavenge reactive oxygen species (ROS), enhance antioxidant defenses, and modulate oxidative stress pathways

Research applications include wound healing, collagen synthesis, antioxidant gene activation, and fibroblast stimulation

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However, rapid maternal weight loss may affect milk production and composition