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Its just that among the non-obese, the semaglutide group happened to start at a lower baseline

Mice treated with antibiotics or reared germ free are resistant to KD-mediated seizure protection, whereas enrichment of Akkermansia muciniphila and Parabacteroides populations restores anti-epileptic effect of KD (76)

Conversely, SCFAs, as key microbial metabolites, can reverse IEC damage: SCFAs interact with G-protein-coupled receptors (GPCR41 and GPCR43) on IECs to induce enteroendocrine hormone release, thereby modulating disease processes (76)

Redox Signal 19 , 708722 (2013)

This is a critical distinction that allows legitimate scientific research to continue within the existing regulatory framework