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Most GI side effects peak between weeks four and eight and resolve by week twelve for the majority of users

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Upregulation of vitamin D regulatory genes can beneficially increase 25(OH)VD levels and the metabolic actions of 1,25(OH) 2 VD [27,28]

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later