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You would have two compounds competing for GLP-1 binding sites while potentially amplifying side effects like nausea beyond tolerable levels

The mechanism of action of these drugs is mainly achieved through antioxidant effects and the clearance of free radicals to achieve therapeutic effects

He is the primary sponsor of the legislation

10.1016/S2213-8587(19)30422-X Summary Keywords GLP-1 receptor agonists, diabetes, coronary artery disease, acute and chronic coronary syndromes, atherosclerosis, coronary microcirculation Citation Pahud de Mortanges A, Sinaci E, Salvador Jr D, Bally L, Muka T, Wilhelm M and Bano A (2022) GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events

So its a case of leapfrogging and iterative improvement