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Exploring N-Alkylation and C-Alkylation Another strategy to enhance the enzymaric stability of peptides is the replacement of a natural -residue with analogues featuring a methyl group on the N atom, known as N-Me- analogues (Figure d)

Moreover, vitamin D deficiency has been correlated with higher titers of anti-thyroid autoantibodies, suggesting a role for vitamin D supplementation as an adjunctive tool for the therapy of thyroid autoimmune diseases [105]

However, the long-term safety data are limited

information on frequency data for each variant is outlined in Table 1

Cleavage site mapping was carried out on a Waters ACQUITY UPLCTQD with PDA detection (190-400 nm)