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Clinical trials have demonstrated varying degrees of weight loss depending on the specific agent and dosage: semaglutide 2.4mg (Wegovy) produces approximately 15% weight loss at 68 weeks, liraglutide 3mg (Saxenda) typically achieves 5-8% weight loss, while tirzepatide has shown up to 20% weight reduction in obesity trials

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Liposome-mediated RNA interference delivery against Erk1 and Erk2 does not equally promote chemosensitivity in human hepatocellular carcinoma cell line HepG2