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Moreover, since the inception of this study, multiple metabolic mechanisms promoting drug resistance have been suggested for 5FU treatment, including changes in amino acid metabolism 69,70 , serine and glycine metabolism 71,72,73 and glycolysis 74,75 , corroborated within our study and independently validating our findings

This work was supported in part by JSPS KAKENHI Grants-in-Aid for Scientific Research (JP16K08635 to K.N

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