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The copper binding occurs through a square-planar pyramid configuration involving nitrogen from histidines imidazole side chain, nitrogen from glycines alpha-amino group, deprotonated amide nitrogen of the glycine-histidine peptide bond, and carboxyl oxygen from lysine

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They are due to an increase in size of the melanocytes, not number of the melanocytes, and are evidence of UVR damage (Figure 7-2)