Severe Gastrointestinal Disease Individuals with high-risk GI conditions, like Crohns, ulcerative colitis, or bowel blockages, might not tolerate retatrutide
Weve researched the best GLP-1-specific cookbooks (and some more generalized ones) to make eating feel easier and to help reduce some of the side effects and risks associated with inadequate nutrition while taking a GLP-1
The glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and now next-generation multi-agonists that include GLP-1 activity, are producing average weight reductions far larger than previously expected from drugs, reshaping clinical practice and how clinicians and patients think about obesity treatment
The FDA has also raised concerns about unapproved GLP-1 products, and the World Health Organization has reported finding counterfeit versions of established GLP-1 medications in several countries, including the United States
Li, Zhou, Cong, and colleagues addressed this in Cell Discovery in 2024 by publishing cryo-electron microscopy structures of retatrutide bound to the GLP-1RGs, GIPRGs, and GCGRGs complexes [2]