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These shortcomings underscore the urgency for transformative strategies such as Cellular Therapy and Stem Cells for Insomnia , capable of restoring neuronal function, modulating systemic inflammation, and realigning circadian dynamics from within [6-10]

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Key modulations are dependent on tumor cell metabolism, cell interactions in TME, tumor heterogeneity, and whole-body metabolism homeostasis (Elia and Haigis, 2021)