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In particular, acetate, the most abundant SCFA, may enhance GLP-1 and PYY secretion in the colon and improve metabolic health by modulating adipose tissue function, increasing insulin sensitivity and oxidative capacity, promoting satiety, and regulating insulin secretion

PMID: 32798065

Hence, it appears that the antidepressant effects resulting from GLP-1 receptor activation by semaglutide may be deeply intertwined with its ability to mitigate neurodegeneration and inflammation

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