soul trial oral semaglutide cardiovascular outcomes 2024 nejm results and in Type 2 Diabetes Emily Kronau, PharmD, MBA (@Phar_em_D)

Nat Rev Drug Discov (2017) 16(7):47286

doi: 10.1073/pnas.1921828118 133

Early treatment challenges sometimes cause patients to stop prematurely because they mistake slow initial progress for treatment failure

Side effects (GI upset, headaches, fatigue, rare vision or kidney issues) Reaching weight or A1c goals Insurance or cost issues Life events (pregnancy, surgery, etc.) Supply shortages Doctors recommendation Stopping is commonand its often more challenging than expected

Summary of GLP-1 Medicine Options Today, GLP-1 medicines fall into four broad groups: Daily injectable GLP-1 medicines Weekly injectable GLP-1 medicines Oral GLP-1 tablets Oral GLP-1 medicines under development Each option differs in dosing, convenience, and suitability, which is why doctors individualise treatment plans