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First, we assessed the gene expression levels of ACTA2 and SM22 , known gene markers for the activated myofibroblastic phenotype 40

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The dissociation between the TCA cycle, -oxidation, and a dysfunctional ETC reflects impaired lipid metabolism and is a major contributor to hepatic oxidative stress [46]

A few factors can shape outcomes: Starting weight and body composition Consistency with injections and follow-up The specific medication and dose tolerated Nutrition quality and protein intake Physical activity, especially strength work Sleep, stress, and hormonal balance Other medical conditions or medications These details help explain why GLP-1 weight loss results are best discussed in a medical setting instead of being judged against social media updates or celebrity headlines

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