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Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: a randomized double-blind, placebo-controlled clinical study

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In the case of the silver(I) complex, coordination with curcumin did not enhance antibacterial activity compared with the free ligand, suggesting that metal binding may alter functional groups responsible for biological activity

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So whether you drink right before bed and have difficulty falling asleep or wake up later in the night, alcohol might be the culprit