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Free radicals and oxidative stress not only damage proteins but also attack DNA, leading to gene mutations and even cancer

NF-B, inflammation, and metabolic disease

The inhibition may conceivably suppress the inflammatory response, reducing the overall stress on cells

Sm-TSP-2/Alhydrogel (Sm-TSP-2/Al ) with or without Glucopyranosyl Lipid Adjuvant in an Aqueous Formulation (GLA-AF) was first tested in a Phase 1 dose-escalation trial among healthy adults from a Sm non-endemic area (NCT02337855) (72)

The level of testicular GH was found to be significantly less than that observed in the pituitary, and thus testicular GH is expected to act locally and not systemically (84)