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Because copper is a required cofactor for numerous enzymes involved in cellular metabolism and antioxidant activity, researchers studying GHK-Cus copper-binding properties often position it as a tool for understanding copper-dependent signaling pathways generally, not just those specific to skin or tissue repair

Human Studies Human data remain limited, and most studies are small, single-center, or use copper peptide formulations combined with other ingredients (which makes it hard to isolate GHK-Cu's specific contribution): A 2016 Lee et al

doi: 10.1093/intimm/dxh186 61 GeijtenbeekTB

10.1038/s41423-021-00768-8 107 TsubotaA.KumadaH.AraseY.ChayamaK.SaitohS.IkedaK.et al (1999)