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The coded and actual levels of the experimental variables, along with the response variables, are presented in Supplementary Table S3

Alpha-MSH interacts with various melanocortin receptors (MCRs) in the body, affecting multiple physiological processes

This finding was significant enough that the tirzepatide drug label now advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

These symptoms would develop gradually with chronic overexposure, not suddenly after a single dose