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Additionally, the administration of oral GLP-1 drugs requires strict guidance: for example, semaglutide must be taken on an empty stomach in the morning, with no more than 120 mL of water, and patients must wait at least 30 minutes before having breakfast
This combination is widely studied in experimental models exploring synergistic peptide activity and regulatory endocrine processes
Diarrhea is usually mild to moderate and often improves over time as the digestive system adjusts to medication
