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Sirtuins, particularly SIRT1 [60], SIRT2 [61], and SIRT3 [62], decline with age

The process begins with the formation of transient adhesive interactions between free-flowing leukocytes and activated endothelial cells

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European Pharmacopoeia PPAR peroxisome proliferator-activated receptor gamma ROS reactive oxygen species THC tetrahydrocannabinol TNF- tumor necrosis factor- Ttr transthyretin TuJ-1 neuron-specific class III beta-tubulin VCAM-1 vascular cell adhesion molecule-1 References 1 AbuhasiraR.NovackV