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The 1.0 mg dose kept most of the 2.4 mg weight effect in the STEP 2 comparison, and 0.5 mg has years of use behind it

As part of the evolving R&D pipeline, Figure 3 summarises the emerging research frontiers into the potential therapeutic applications of GLP-1s beyond cardiometabolic conditions, including neurodegeneration, addiction, mental health, cancer, womens health and asthma

Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range

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