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Comprehensive analysis of bioactive compounds in Crocus sativus stamens extracts by HPLC-DAD: investigating antidiabetic activity via in vitro , in vivo , and molecular docking simulation

SIRT3 (widely expressed in mitochondria-rich tissues such as kidney, heart, brain, and liver tissue), is linked to age-related diseases, cancer, and heart and metabolic diseases, suggesting that it may be a potential therapeutic target [144]