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The cold sensation experienced by many patients is likely multifactorial, involving changes in body composition, metabolic rate, and possibly other mechanisms that are not yet fully understood

However, if you experience severe, persistent vomiting, abdominal pain, or inability to keep fluids down, contact your healthcare provider to rule out other conditions

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D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell