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Such a robust fibrosis can be induced in rodents with prolonged or repeated exposure to certain chemicals (carbon tetrachloride, alcohol, tetrachlorovinphos, diallylphthalate), dietary lipotrope deficiency, or chronic hepatitis secondary to persistent infection (Ward 1997)

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Reduction of ScGrx7 by GSH is slower than the oxidation by GSSCys (unless Lys105 is replaced, which decelerates the oxidative half-reaction even more than the reductive half-reaction owing to the dual activator function)

More melanin precursors are channeled into the production of Pheomelanin

References Pathria, G