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Patients may experience slower weight loss than expected or weight stability rather than reduction when taking both medications concurrently

placebo ranged from -8.8% (95% CI -10.3, -6.3) to -6.9% (95% CI -9.1, -4.7) from no diuretics to the highest loop diuretic dose category

It is also worth noting that both medications can affect the central nervous system, and their combined use may lead to unpredictable outcomes, especially in those with compromised health or those taking multiple medications