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Comparing Cagrilintide and Tirzepatide Cagrilintide and tirzepatide are distinct peptides: Mechanism: Cagrilintide targets amylin receptors

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The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex

Ortiz-Pujols agrees, noting that finding the right medication and dosage is likely just a matter of trial and error

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