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doi: 10.1094/MPMI-12-12-0286-R 2 AmariK.Daz-VivancosP.PallsV.Snchez-PinaM

Its most well-characterized mechanism involves stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, which underlies its effects on skin elasticity, firmness, and wound repair

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Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]