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This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223,224,225]

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Considering the multiple alterations in the endocrine control of eating behavior in patients with PWS that involve both central and peripheral signals of hunger-satiety network, a number of studies have been performed to modulate hyperphagia [31]

Polysaccharide based nanogels in the drug delivery system: application as the carrier of pharmaceutical agents

If patients feel empowered and informed, they are more likely to start and stay on therapy