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J Transl Med 17:55 Tsai SY, Lin CL, Shih SC, Hsu CW, Leong KH, Kuo CF, Lio CF, Chen YT, Hung YJ, Shi L (2018) Increased risk of chronic fatigue syndrome following burn injuries

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Accordingly, the present invention provides improved processes for the preparation of orlistat of Formula (I) comprising alkanoylating (S)-leucine (S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl dodecyl ester (amino orlistat) of Formula (II), Amino orlistat may be obtained by methods known in the art including, for example, U.S