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Sleep and stress management Poor sleep amplifies pain perception through multiple mechanisms, including increased cortisol, reduced endogenous opioid activity, and impaired glymphatic clearance of inflammatory mediators

Psychiatry 127 ZhouL.YangY.MouL.XiaX.LiuM.XuL.et al (2025)

In some cases especially when hormones like IGF-1 are involved prescription medications that reduce oil production or block androgen receptors may help