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This effect is real, measurable, and one of the most therapeutically meaningful aspects of these medications

GLP-1RAs attenuate apoptosis in cardiomyocytes induced by hyperglycemia via inhibiting receptor of advanced glycation end products (RAGE) receptor [82]

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Until now the tests with exendin-4 had only been done in mice and the company was unsure what would happen when it was given to humans