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NLY01 exerts its neuroprotective effect by potently suppressing this pathogenic inflammatory axis, thereby attenuating the formation of cytotoxic A1 astrocytes and preserving RGC viability [42]

In addition to these completed trials, The Study of Heart and Kidney Protection With Empagliflozin (EMPA-KIDNEY, NCT03594110) is currently underway and is recruiting a broader group of participants with eGFRs as low as 20 mL/min/1.73 m 2 , without the requirement for albuminuria in patients with lower eGFR between 20 to 45 mL/min/1.73 m 2

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