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Regression lines were computed with GraphPad Prism 9.0 using the one-phase decay equation

Specific Populations Age, Race, Body Mass Index and Gender Effect of age, race, body mass index (BMI) and gender on the pharmacokinetics of insulin glargine products has not been evaluated

The data regarding the participants demographic, clinical and therapeutic characteristics, outcomes and other important parameters were extracted from tabular, textual and graphic sources of the published research papers independently by two researchers and were cross-checked later (kappa = 0.95)

According to Lillys release, the trial met its primary endpoint: participants titrating up to the highest orforglipron dose lost 27.3 lb (12.4%) of body weight at 72 weeks versus about 0.9% weight loss with placebo