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With the help of another family of enzymes (glutathione-S-transferases), glutathione has the ability to plant itself on toxins, flagging them as hazardous

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Understanding the basic mechanisms underlying the ROS-mediated fibrogenesis provides valuable information on the search for effective antifibrogenic therapies

Using multiple high-throughput proteomics assays in two independent cohorts of konzo-affected children compared to unrelated individuals (Discovery) or their unaffected sibling (Validation) respectively, we demonstrate that levels of the critical plasma-based antioxidant enzyme Glutathione Peroxidase 3 (GPx3) are significantly reduced in those affected