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For example, several gastrointestinal side effects are highly associated with GLP-1s, including nausea, vomiting, diarrhea and constipation in data from over 33,000 patients

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NEJM 2025 (REDEFINE-2) Novo Nordisk FDA NDA submission announcement (December 18, 2025) Eli Lilly TRIUMPH-4 topline results (December 2025) Frequently Asked Questions Retatrutide produces higher weight loss at 28.7% versus CagriSema's 20.4%a difference of 21 pounds for a 250-pound person

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Biochem Cell Biol 96:713725