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With declining estrogen, your brain responds less robustly to the satiety signals that GLP-1 medications are designed to amplify

Results A basement membrane glycoprotein synergistically interacts with glp-1/Notch In C

Liu et al., 2019

If you are experiencing such problems, in the first instance you should see your GP who will undertake a blood test, review your symptoms, and diagnose any deficiency, alongside any need for dietary changes, oral supplementation, or prescribed injections of vitamin B12

There are reports of beneficial changes in the gut microbiota by biguanides, but few other anti-diabetic drugs are reported 6,7,8