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Functionally, melatonin can link changes in external light signals and multiple physiological activity rhythms ( Melatonin was originally isolated and identified from the pineal glands of animals ( Additionally, many studies have demonstrated that some bacteria and fungi can synthesize melatonin ( Eryrobacter longusits , demonstrating that it could synthesize and secrete melatonin under weak light conditions

Previous published findings from our lab have showed that using in vitro antibiotics at 1/10 MIC PZA (5 g/ml) and 1/10 MIC INH (0.0125 g/ml) was able to reduce the burden of M.tb

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